Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G
نویسندگان
چکیده
منابع مشابه
Inhibition of neuronal voltage-gated sodium channels by brilliant blue G.
Brilliant blue G (BBG), best known as an antagonist of P2X7 receptors, was found to inhibit voltage-gated sodium currents in N1E-115 neuroblastoma cells. Sodium currents elicited from a holding potential of -60 mV were blocked with an IC(50) of 2 μM. Block was enhanced in a use-dependent manner at higher stimulation rates. The voltage-dependence of inactivation was shifted in the hyperpolarizin...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2011
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.110.070276